Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers. / Nörby, Ulrika; Källén, Karin; Eiermann, Birgit; Korkmaz, Seher; Winbladh, Birger; Gustafsson, Lars L.

I: European Journal of Clinical Pharmacology, Vol. 69, Nr. 4, 2013, s. 889-899.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

APA

CBE

MLA

Vancouver

Author

Nörby, Ulrika ; Källén, Karin ; Eiermann, Birgit ; Korkmaz, Seher ; Winbladh, Birger ; Gustafsson, Lars L. / Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers. I: European Journal of Clinical Pharmacology. 2013 ; Vol. 69, Nr. 4. s. 889-899.

RIS

TY - JOUR

T1 - Drugs and Birth Defects: a knowledge database providing risk assessments based on national health registers

AU - Nörby, Ulrika

AU - Källén, Karin

AU - Eiermann, Birgit

AU - Korkmaz, Seher

AU - Winbladh, Birger

AU - Gustafsson, Lars L.

PY - 2013

Y1 - 2013

N2 - To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following standardized working procedures, a statement is compiled for each substance, which is also classified into one of three categories depending on the estimated risk level. The final documents include drug product names on the market, via linkage to a medicinal products register. The information is free and published on the website www.janusinfo.se. It can also be used as an integrated part of electronic health records. The database covers assessments of fetal risks for close to 1,250 medicinal drug substances on the Swedish market. Each year, 96,000 searches are made, which might be compared to the around 100,000 children born in Sweden yearly. Apart from the Swedish Physicians' Desk Reference (Fass), the database is the most commonly used resource among specialists within gynaecology and perinatal medicine for information on drugs during pregnancy. A non-commercial knowledge base with assessments of fetal risk of different drugs is valued by health care professionals and is used extensively in Sweden. Based on analyses of national health registers, the database provides unique information on teratogenic drug risks.

AB - To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following standardized working procedures, a statement is compiled for each substance, which is also classified into one of three categories depending on the estimated risk level. The final documents include drug product names on the market, via linkage to a medicinal products register. The information is free and published on the website www.janusinfo.se. It can also be used as an integrated part of electronic health records. The database covers assessments of fetal risks for close to 1,250 medicinal drug substances on the Swedish market. Each year, 96,000 searches are made, which might be compared to the around 100,000 children born in Sweden yearly. Apart from the Swedish Physicians' Desk Reference (Fass), the database is the most commonly used resource among specialists within gynaecology and perinatal medicine for information on drugs during pregnancy. A non-commercial knowledge base with assessments of fetal risk of different drugs is valued by health care professionals and is used extensively in Sweden. Based on analyses of national health registers, the database provides unique information on teratogenic drug risks.

KW - Pregnancy

KW - Teratogenic effects

KW - Drug-induced abnormalities

KW - Drug-induced

KW - perinatal effects

KW - Health registers

KW - Knowledge bases

KW - Information

KW - systems

U2 - 10.1007/s00228-012-1399-y

DO - 10.1007/s00228-012-1399-y

M3 - Article

VL - 69

SP - 889

EP - 899

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 1432-1041

IS - 4

ER -