Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets. / Feet, B A; Brun, N C; Hellström-Westas, Lena; Svenningsen, Niels W; Greisen, G; Saugstad, O D.

I: Journal of Applied Physiology, Vol. 84, Nr. 4, 1998, s. 1208-1216.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Feet, BA, Brun, NC, Hellström-Westas, L, Svenningsen, NW, Greisen, G & Saugstad, OD 1998, 'Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets', Journal of Applied Physiology, vol. 84, nr. 4, s. 1208-1216.

APA

Feet, B. A., Brun, N. C., Hellström-Westas, L., Svenningsen, N. W., Greisen, G., & Saugstad, O. D. (1998). Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets. Journal of Applied Physiology, 84(4), 1208-1216.

CBE

Feet BA, Brun NC, Hellström-Westas L, Svenningsen NW, Greisen G, Saugstad OD. 1998. Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets. Journal of Applied Physiology. 84(4):1208-1216.

MLA

Vancouver

Feet BA, Brun NC, Hellström-Westas L, Svenningsen NW, Greisen G, Saugstad OD. Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets. Journal of Applied Physiology. 1998;84(4):1208-1216.

Author

Feet, B A ; Brun, N C ; Hellström-Westas, Lena ; Svenningsen, Niels W ; Greisen, G ; Saugstad, O D. / Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets. I: Journal of Applied Physiology. 1998 ; Vol. 84, Nr. 4. s. 1208-1216.

RIS

TY - JOUR

T1 - Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets

AU - Feet, B A

AU - Brun, N C

AU - Hellström-Westas, Lena

AU - Svenningsen, Niels W

AU - Greisen, G

AU - Saugstad, O D

PY - 1998

Y1 - 1998

N2 - We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.

AB - We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.

KW - asphyxia

KW - electroencephalography

KW - near-infrared spectrophotometry

KW - hypoxanthine

KW - newborn piglets

M3 - Article

VL - 84

SP - 1208

EP - 1216

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 1522-1601

IS - 4

ER -