Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study

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Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis : A Nordic Multicenter Study. / Auråen, Henrik; Durheim, Michael Thomas; Dellgren, Göran; Hämmäinen, Pekka; Larsson, Hillevi; Geiran, Odd; Schultz, Hans Henrik Lawaetz; Leuckfeld, Inga; Iversen, Martin; Fiane, Arnt; Holm, Are Martin.

I: Transplantation, Vol. 103, Nr. 4, 2019, s. 807-814.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Auråen, H, Durheim, MT, Dellgren, G, Hämmäinen, P, Larsson, H, Geiran, O, Schultz, HHL, Leuckfeld, I, Iversen, M, Fiane, A & Holm, AM 2019, 'Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study', Transplantation, vol. 103, nr. 4, s. 807-814. https://doi.org/10.1097/TP.0000000000002402

APA

Auråen, H., Durheim, M. T., Dellgren, G., Hämmäinen, P., Larsson, H., Geiran, O., ... Holm, A. M. (2019). Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study. Transplantation, 103(4), 807-814. https://doi.org/10.1097/TP.0000000000002402

CBE

Auråen H, Durheim MT, Dellgren G, Hämmäinen P, Larsson H, Geiran O, Schultz HHL, Leuckfeld I, Iversen M, Fiane A, Holm AM. 2019. Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study. Transplantation. 103(4):807-814. https://doi.org/10.1097/TP.0000000000002402

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Author

Auråen, Henrik ; Durheim, Michael Thomas ; Dellgren, Göran ; Hämmäinen, Pekka ; Larsson, Hillevi ; Geiran, Odd ; Schultz, Hans Henrik Lawaetz ; Leuckfeld, Inga ; Iversen, Martin ; Fiane, Arnt ; Holm, Are Martin. / Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis : A Nordic Multicenter Study. I: Transplantation. 2019 ; Vol. 103, Nr. 4. s. 807-814.

RIS

TY - JOUR

T1 - Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis

T2 - A Nordic Multicenter Study

AU - Auråen, Henrik

AU - Durheim, Michael Thomas

AU - Dellgren, Göran

AU - Hämmäinen, Pekka

AU - Larsson, Hillevi

AU - Geiran, Odd

AU - Schultz, Hans Henrik Lawaetz

AU - Leuckfeld, Inga

AU - Iversen, Martin

AU - Fiane, Arnt

AU - Holm, Are Martin

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Organs from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are unclear. This multicenter study reviews all bilateral lung transplantations (BLTx) from donors 55 years or older stratified by recipient diagnosis and compares outcomes with transplantations from younger donors. METHODS: All BLTx recipients (excluding retransplantation) at 5 Scandiatransplant centers between 2000 and 2013 were included (n = 913). Recipients were stratified to diagnosis groups including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and "other." Intensive care unit (ICU) length of stay (LOS) and survival were assessed. RESULTS: Overall, there was no difference in survival among patients transplanted from donors 55 years or older compared with younger donors. However, in CF recipients, donor age 55 years or older was associated with inferior survival (P = 0.014), and this remained significant in a multivariate model (hazard ratio, 5.0; 95% confidence interval, 1.8-14.1; P = 0.002). There was no significant effect of donor age on survival in recipients with COPD, ILD, or in the "other" group in multivariate models. Utilization of older donors was associated with increased ICU LOS for recipients with CF and ILD, but not in the COPD or "other" group. CONCLUSIONS: The BLTx recipients with CF had inferior survival and longer ICU LOS when receiving organs from donors 55 years or older. Recipients with COPD, ILD, or in the "other" group did not have inferior survival in multivariate models.

AB - BACKGROUND: Organs from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are unclear. This multicenter study reviews all bilateral lung transplantations (BLTx) from donors 55 years or older stratified by recipient diagnosis and compares outcomes with transplantations from younger donors. METHODS: All BLTx recipients (excluding retransplantation) at 5 Scandiatransplant centers between 2000 and 2013 were included (n = 913). Recipients were stratified to diagnosis groups including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and "other." Intensive care unit (ICU) length of stay (LOS) and survival were assessed. RESULTS: Overall, there was no difference in survival among patients transplanted from donors 55 years or older compared with younger donors. However, in CF recipients, donor age 55 years or older was associated with inferior survival (P = 0.014), and this remained significant in a multivariate model (hazard ratio, 5.0; 95% confidence interval, 1.8-14.1; P = 0.002). There was no significant effect of donor age on survival in recipients with COPD, ILD, or in the "other" group in multivariate models. Utilization of older donors was associated with increased ICU LOS for recipients with CF and ILD, but not in the COPD or "other" group. CONCLUSIONS: The BLTx recipients with CF had inferior survival and longer ICU LOS when receiving organs from donors 55 years or older. Recipients with COPD, ILD, or in the "other" group did not have inferior survival in multivariate models.

U2 - 10.1097/TP.0000000000002402

DO - 10.1097/TP.0000000000002402

M3 - Article

VL - 103

SP - 807

EP - 814

JO - Transplantation bulletin

JF - Transplantation bulletin

SN - 1534-6080

IS - 4

ER -