Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: the randomized SOCCER trial

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

OBJECTIVE: Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).

MATERIALS AND METHODS: This study was a randomized-controlled trial conducted at two university hospitals in Sweden. Normoxic STEMI patients were randomized in the ambulance to either supplemental O2 (10 l/min) or room air until the conclusion of the PCI. CMR was performed 2-6 days after the inclusion. The primary endpoint was the myocardial salvage index assessed by CMR. The secondary endpoints included infarct size and myocardium at risk.

RESULTS: At inclusion, the O2 (n=46) and air (n=49) patient groups had similar patient characteristics. There were no significant differences in myocardial salvage index [53.9±25.1 vs. 49.3±24.0%; 95% confidence interval (CI): -5.4 to 14.6], myocardium at risk (31.9±10.0% of the left ventricle in the O2 group vs. 30.0±11.8% in the air group; 95% CI: -2.6 to 6.3), or infarct size (15.6±10.4% of the left ventricle vs. 16.0±11.0%; 95% CI: -4.7 to 4.1).

CONCLUSION: In STEMI patients undergoing acute PCI, we found no effect of high-flow oxygen compared with room air on the size of ischemia before PCI, myocardial salvage, or the resulting infarct size. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
  • Annan klinisk medicin

Nyckelord

Originalspråkengelska
Sidor (från-till)78-84
Antal sidor7
TidskriftEuropean Journal of Emergency Medicine
Volym25
Utgivningsnummer2
Tidigt onlinedatum2016 nov 23
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Ardavan Khoshnood, 2018 okt 19, I : BMC Emergency Medicine. 18, 35.

Forskningsoutput: TidskriftsbidragDebate/Note/Editorial

Ardavan Khoshnood, Akbarzadeh, M., Marcus Carlsson, David Sparv, Bhiladvala, P., Mokhtari, A., David Erlinge & Ulf Ekelund, 2018, I : Scandinavian Cardiovascular Journal. 52, 2, s. 69-73 5 s.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Sepehrvand, N., James, S. K., Stub, D., Ardavan Khoshnood, Ezekowitz, J. A. & Hofmann, R., 2018, I : Heart. 104, 20, s. 1691-1698

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Relaterade aktiviteter

Khoshnood, A. (Inbjuden talare)
2018 mar 9

Aktivitet: Föredrag eller presentationInbjuden talare

Khoshnood, A. (Talare)
2017 okt 26

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Khoshnood, A. (presentatör)
2017 maj 19

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Ardavan Khoshnood (Mottagare), 2016

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