Effects of neutral and dibasic amino acids on the in vitro release of insulin

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The insulin-releasing ability of some neutral and di-basic amino acids was studied in an in vitro system using micro-dissected pancreatic islets with a high proportion of insulin-producing β-cells. The neutral amino acids l-alanine and α-aminoisobutyric acid had no substantial effects on basal and glucose-stimulated insulin release. In contrast, 5–20 mm of the dibasic amino acid l-arginine gradually enhanced the insulin release induced by 10 mm glucose. A critical glucose concentration must be reached before l-arginine can act as an insulin secretagogue. N-methyl-l-arginine lacked the stimulatory ability. Co-transport of neutral amino acids and sodium does not elicit insulin release in adult mouse β-cells. There may, however, be a close relationship between the transport site for l-arginine and a receptor triggering insulin release.

Detaljer

Författare
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes

Nyckelord

Originalspråkengelska
Sidor (från-till)22-30
Antal sidor9
TidskriftHormone Research in Paediatrics
Volym3
Utgåva nummer1
StatusPublished - 1972 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa