Effects of neutral and dibasic amino acids on the in vitro release of insulin
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
The insulin-releasing ability of some neutral and di-basic amino acids was studied in an in vitro system using micro-dissected pancreatic islets with a high proportion of insulin-producing β-cells. The neutral amino acids l-alanine and α-aminoisobutyric acid had no substantial effects on basal and glucose-stimulated insulin release. In contrast, 5–20 mm of the dibasic amino acid l-arginine gradually enhanced the insulin release induced by 10 mm glucose. A critical glucose concentration must be reached before l-arginine can act as an insulin secretagogue. N-methyl-l-arginine lacked the stimulatory ability. Co-transport of neutral amino acids and sodium does not elicit insulin release in adult mouse β-cells. There may, however, be a close relationship between the transport site for l-arginine and a receptor triggering insulin release.
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Tidskrift||Hormone Research in Paediatrics|
|Status||Published - 1972 jan 1|
|Peer review utförd||Ja|