Efficient estimation of emission probabilities in profile hidden Markov models.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Profile hidden Markov models provide a sensitive method for performing sequence database search and aligning multiple sequences. One of the drawbacks of the hidden Markov model is that the conserved amino acids are not emphasized, but signal and noise are treated equally. For this reason, the number of estimated emission parameters is often enormous. Focusing the analysis on conserved residues only should increase the accuracy of sequence database search.

Detaljer

Författare
Externa organisationer
  • External Organization - Unknown
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Bioinformatik och systembiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)2359-2368
TidskriftBioinformatics
Volym19
Utgivningsnummer18
StatusPublished - 2003
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa