Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain

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Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain. / Bassant, M H; Joly, M; Nilsson, O G; Björklund, A; Lamour, Y.

I: Brain Research, Vol. 460, Nr. 1, 13.09.1988, s. 8-16.

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T1 - Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain

AU - Bassant, M H

AU - Joly, M

AU - Nilsson, O G

AU - Björklund, A

AU - Lamour, Y

PY - 1988/9/13

Y1 - 1988/9/13

N2 - Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.

AB - Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.

KW - Acetylcholine/pharmacology

KW - Animals

KW - Brain/physiology

KW - Carbachol/pharmacology

KW - Electrophysiology/methods

KW - Glutamates/pharmacology

KW - Glutamic Acid

KW - Male

KW - Nerve Tissue/transplantation

KW - Neurons/drug effects

KW - Neurotransmitter Agents/pharmacology

KW - Norepinephrine/pharmacology

KW - Rats

KW - Rats, Inbred Strains

KW - Reference Values

KW - Serotonin/pharmacology

KW - gamma-Aminobutyric Acid/pharmacology

U2 - 10.1016/0006-8993(88)90424-6

DO - 10.1016/0006-8993(88)90424-6

M3 - Article

C2 - 2905923

VL - 460

SP - 8

EP - 16

JO - Brain Research

JF - Brain Research

SN - 1872-6240

IS - 1

ER -