Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease

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Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease. / Wirtwein, Marcin; Melander, Olle; Sjőgren, Marketa; Hoffmann, Michal; Narkiewicz, Krzysztof; Gruchala, Marcin; Sobiczewski, Wojciech.

I: Blood Pressure, Vol. 26, Nr. 3, 2017, s. 174-180.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Wirtwein, Marcin ; Melander, Olle ; Sjőgren, Marketa ; Hoffmann, Michal ; Narkiewicz, Krzysztof ; Gruchala, Marcin ; Sobiczewski, Wojciech. / Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease. I: Blood Pressure. 2017 ; Vol. 26, Nr. 3. s. 174-180.

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TY - JOUR

T1 - Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease

AU - Wirtwein, Marcin

AU - Melander, Olle

AU - Sjőgren, Marketa

AU - Hoffmann, Michal

AU - Narkiewicz, Krzysztof

AU - Gruchala, Marcin

AU - Sobiczewski, Wojciech

PY - 2017

Y1 - 2017

N2 - Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.

AB - Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.

KW - coronary artery disease

KW - dipping

KW - DNA polymorphism

KW - hypertension

UR - http://www.scopus.com/inward/record.url?scp=85009760495&partnerID=8YFLogxK

U2 - 10.1080/08037051.2016.1273741

DO - 10.1080/08037051.2016.1273741

M3 - Article

VL - 26

SP - 174

EP - 180

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 3

ER -