Elevated intracranial pressure or subarachnoid blood responsible for reduction in cerebral blood flow after SAH

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

Abstract

Background. The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the extravasated blood that is responsible for cerebral ischemia and cerebral vasoconstriction observed following SAH. Method. Three groups of animals were studied; (1) cisternal injection of 250 mu l blood (SAH), (2) injection of 250 mu l NaCl (saline) or (3) same procedure in every detail but no fluid injection (sham). Two days after the treatment, an autoradiographic technique was used to investigate the cerebral blood flow (CBF). Findings. Both SAH (blood+ ICP) and saline injection (ICP only) resulted in significantly reduced regional and global CBF after as compared to sham/control. Conclusions. This study revealed that both the elevation of ICP and A Subarachnoid blood per se contribute approximately equally to the SAH induced effects.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Annan klinisk medicin

Nyckelord

Originalspråkengelska
Titel på värdpublikationCerebral Vasospasm: New Strategies in Research and Treatment
FörlagSpringer
Sidor231-233
Volym104
ISBN (tryckt)978-3-211-75717-8
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa
Evenemang9th International Conference on Cerebral Vasospasm - Istanbul, Turkiet
Varaktighet: 2006 jun 272006 jun 30

Publikationsserier

Namn
Volym104
ISSN (tryckt)0065-1419

Konferens

Konferens9th International Conference on Cerebral Vasospasm
LandTurkiet
OrtIstanbul
Period2006/06/272006/06/30