Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

Detaljer

Författare
  • Helen M Colhoun
  • Angela C Shore
  • Carlo Palombo
  • Andrea Natali
  • Andreas Edsfeldt
  • Gunilla Nordin Fredrikson
  • Gerd Östling
  • Kunihiko Aizawa
  • Francesco Casanova
  • Kim Gooding
  • David Strain
  • Faisel Kahn
  • Helen C Looker
  • Fiona Adams
  • Jill Belch
  • Silvia Pinnoli
  • Elena Venturi
  • Michaela Kozakova
  • Li-Ming Gan
  • Volker Schnecke
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)1723-1731
TidskriftArteriosclerosis, Thrombosis and Vascular Biology
Volym35
Utgivningsnummer7
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa