Elevated urine levels of heparin-binding protein in children with urinary tract infection.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.

METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.

RESULTS: Fifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels.

CONCLUSION: The results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI.


Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Sidor (från-till)1301-1308
TidskriftPediatric Nephrology
Utgåva nummer8
StatusPublished - 2012
Peer review utfördJa

Relaterad forskningsoutput

CHARLOTT KJÖLVMARK, 2016, Lund: Lund University: Faculty of Medicine. 78 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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