Enantiomeric Derivatives of Tokinolide B: Absolute Configuration and Biological Properties

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The enantiomeric lactams (-)-8, (+)-8, (+)-9, and (-)-9 were formed by the reaction of the dimeric phthalide rac-tokinolide B (rac-3) with (R)-(+)-alpha-methylbenzylamine and (S)-(-)-alpha-methylbenzylamine. The absolute configurations of compounds 8 and 9 were assigned by experimental and theoretically calculated electronic circular dichroism methods for (+)-8 and (-)-9. Compounds 3, 5, (-)-8, (+)-8, (+)-9, and (-)-9 displayed cytotoxic activity toward several human tumor cell lines, with (-)-8 and (-)-9 being the most potent.

Detaljer

Författare
  • Alejandra Leon
  • J. Antonio Cogordan
  • Olov Sterner
  • Guillermo Delgado
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
Sidor (från-till)859-864
TidskriftJournal of Natural Products
Volym75
Utgivningsnummer5
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa