Enantioselective synthesis of anti-beta-amido-alpha-hydroxy esters via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution

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Abstract

The asymmetric transfer hydrogenation of beta-amido-alpha-keto esters providing the corresponding anti-beta-amido-alpha-hydroxy esters via dynamic kinetic resolution is reported. The use of a commercially available, or simply prepared, chiral ruthenium catalyst results in good yields as well as high diastereoselectivities and enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

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Nyckelord

Originalspråkengelska
Sidor (från-till)5266-5268
TidskriftTetrahedron Letters
Volym54
Utgivningsnummer38
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa