Enantioselective Synthesis of Substituted Piperidines by Addition of Aryl Grignard Reagents to Pyridine N-Oxides.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The synthesis of optically active piperidines by enantioselective addition of aryl Grignard reagents to pyridine N-oxides and lithium binolate followed by reduction is reported for the first time. The reaction results in high yields (51-94%) in combination with good ee (54-80%). Some of these products were subsequently recrystallized, affording enhanced optical purities (>99% ee).

Detaljer

Författare
  • Munawar Hussain
  • Thomas Sainte-Luce Banchelin
  • Hans Andersson
  • Roger Olsson
  • Fredrik Almqvist
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
TidskriftOrganic Letters
Tidigt onlinedatum2012 dec 20
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa