Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Estrogen receptor (ER)-positive breast cancer represents the majority (∼70%) of all breast malignancies. In this subgroup of breast cancers, endocrine therapies are effective both in the adjuvant and recurrent settings, although resistance remains a major issue. Several high-throughput approaches have been used to elucidate mechanisms of resistance and to derive potential predictive markers or alternative therapies. In this review, we cover the state-of-the-art of endocrine-resistance biomarker discovery with regard to the latest technological developments, and discuss current opportunities and restrictions for their implementation into a clinical setting.

Detaljer

Författare
Externa organisationer
  • Erasmus University Medical Center
Originalspråkengelska
Sidor (från-till)1181-8
Antal sidor8
TidskriftDrug Discovery Today
Volym21
Utgivningsnummer7
StatusPublished - 2016 jul
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa