Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study

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title = "Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study",
abstract = "Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE2) and 5 alpha-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels > 10 mu mol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.",
author = "Lee, {David M.} and Aslan Ulubaev and Abdelouahid Tajar and Pye, {Stephen R.} and Neil Pendleton and Nitin Purandare and O'Neill, {Terence W.} and O'Connor, {Daryl B.} and Fernand Labrie and Hazel Platt and Debbie Payne and Gyorgy Bartfai and Steven Boonen and Casanueva, {Felipe F.} and Finn, {Joseph D.} and Gianni Forti and Aleksander Giwercman and Han, {Thang S.} and Huhtaniemi, {Ilpo T.} and Krzysztof Kula and Lean, {Michael E. J.} and Margus Punab and Silman, {Alan J.} and Dirk Vanderschueren and Wu, {Frederick C. W.}",
year = "2010",
doi = "10.1530/EJE-09-0970",
language = "English",
volume = "162",
pages = "1155--1164",
journal = "European Journal of Endocrinology",
issn = "1479-683X",
publisher = "Society of the European Journal of Endocrinology",
number = "6",