Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study

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Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study. / Rinaldi, Sabina; Plummer, Martyn; Biessy, Carine; Castellsague, Xavier; Overvad, Kim; Kjaer, Susanne Krueger; Tjonneland, Anne; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Mesrine, Sylvie; Lukanova, Annekatrin; Kaaks, Rudolf; Weikert, Cornelia; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, Bas; van Kranen, Henk J.; Peeters, Petra H. M.; Bakken, Kjersti; Lund, Eiliv; Gram, Inger Torhild; Rodriguez, Laudina; Bosch, F. Xavier; Sanchez, Maria-Jose; Dorronsoro, Miren; Navarro, Carmen; Barricarte Gurrea, Aurelio; Kjellberg, Lennart; Dillner, Joakim; Manjer, Jonas; Butt, Salma; Khaw, Kay-Tee; Wareham, Nicholas; Allen, Naomi E.; Travis, Ruth; Romieu, Isabelle; Ferrari, Pietro; Riboli, Elio; Franceschi, Silvia.

I: Cancer Epidemiology Biomarkers & Prevention, Vol. 20, Nr. 12, 2011, s. 2532-2540.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Rinaldi, S, Plummer, M, Biessy, C, Castellsague, X, Overvad, K, Kjaer, SK, Tjonneland, A, Clavel-Chapelon, F, Chabbert-Buffet, N, Mesrine, S, Lukanova, A, Kaaks, R, Weikert, C, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, B, van Kranen, HJ, Peeters, PHM, Bakken, K, Lund, E, Gram, IT, Rodriguez, L, Bosch, FX, Sanchez, M-J, Dorronsoro, M, Navarro, C, Barricarte Gurrea, A, Kjellberg, L, Dillner, J, Manjer, J, Butt, S, Khaw, K-T, Wareham, N, Allen, NE, Travis, R, Romieu, I, Ferrari, P, Riboli, E & Franceschi, S 2011, 'Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study', Cancer Epidemiology Biomarkers & Prevention, vol. 20, nr. 12, s. 2532-2540. https://doi.org/10.1158/1055-9965.EPI-11-0753

APA

Rinaldi, S., Plummer, M., Biessy, C., Castellsague, X., Overvad, K., Kjaer, S. K., Tjonneland, A., Clavel-Chapelon, F., Chabbert-Buffet, N., Mesrine, S., Lukanova, A., Kaaks, R., Weikert, C., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Agnoli, C., ... Franceschi, S. (2011). Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study. Cancer Epidemiology Biomarkers & Prevention, 20(12), 2532-2540. https://doi.org/10.1158/1055-9965.EPI-11-0753

CBE

Rinaldi S, Plummer M, Biessy C, Castellsague X, Overvad K, Kjaer SK, Tjonneland A, Clavel-Chapelon F, Chabbert-Buffet N, Mesrine S, Lukanova A, Kaaks R, Weikert C, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Agnoli C, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita B, van Kranen HJ, Peeters PHM, Bakken K, Lund E, Gram IT, Rodriguez L, Bosch FX, Sanchez M-J, Dorronsoro M, Navarro C, Barricarte Gurrea A, Kjellberg L, Dillner J, Manjer J, Butt S, Khaw K-T, Wareham N, Allen NE, Travis R, Romieu I, Ferrari P, Riboli E, Franceschi S. 2011. Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study. Cancer Epidemiology Biomarkers & Prevention. 20(12):2532-2540. https://doi.org/10.1158/1055-9965.EPI-11-0753

MLA

Vancouver

Author

Rinaldi, Sabina ; Plummer, Martyn ; Biessy, Carine ; Castellsague, Xavier ; Overvad, Kim ; Kjaer, Susanne Krueger ; Tjonneland, Anne ; Clavel-Chapelon, Francoise ; Chabbert-Buffet, Nathalie ; Mesrine, Sylvie ; Lukanova, Annekatrin ; Kaaks, Rudolf ; Weikert, Cornelia ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; van Kranen, Henk J. ; Peeters, Petra H. M. ; Bakken, Kjersti ; Lund, Eiliv ; Gram, Inger Torhild ; Rodriguez, Laudina ; Bosch, F. Xavier ; Sanchez, Maria-Jose ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte Gurrea, Aurelio ; Kjellberg, Lennart ; Dillner, Joakim ; Manjer, Jonas ; Butt, Salma ; Khaw, Kay-Tee ; Wareham, Nicholas ; Allen, Naomi E. ; Travis, Ruth ; Romieu, Isabelle ; Ferrari, Pietro ; Riboli, Elio ; Franceschi, Silvia. / Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study. I: Cancer Epidemiology Biomarkers & Prevention. 2011 ; Vol. 20, Nr. 12. s. 2532-2540.

RIS

TY - JOUR

T1 - Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study

AU - Rinaldi, Sabina

AU - Plummer, Martyn

AU - Biessy, Carine

AU - Castellsague, Xavier

AU - Overvad, Kim

AU - Kjaer, Susanne Krueger

AU - Tjonneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Chabbert-Buffet, Nathalie

AU - Mesrine, Sylvie

AU - Lukanova, Annekatrin

AU - Kaaks, Rudolf

AU - Weikert, Cornelia

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - van Kranen, Henk J.

AU - Peeters, Petra H. M.

AU - Bakken, Kjersti

AU - Lund, Eiliv

AU - Gram, Inger Torhild

AU - Rodriguez, Laudina

AU - Bosch, F. Xavier

AU - Sanchez, Maria-Jose

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Barricarte Gurrea, Aurelio

AU - Kjellberg, Lennart

AU - Dillner, Joakim

AU - Manjer, Jonas

AU - Butt, Salma

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E.

AU - Travis, Ruth

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Riboli, Elio

AU - Franceschi, Silvia

PY - 2011

Y1 - 2011

N2 - Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection-related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E(2)); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone-binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E(2) were calculated from absolute concentrations of T, E(2), and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression. Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile 5.16, 95% CI, 1.50-20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E(2), fE(2), and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR 3.14; 95% CI, 1.21-9.37), whereas E(2) and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women. Conclusions: Our findings suggest for the first time that T and possibly E(2) may be involved in the etiology of ICC. Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532-40. (C) 2011 AACR.

AB - Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection-related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E(2)); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone-binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E(2) were calculated from absolute concentrations of T, E(2), and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression. Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile 5.16, 95% CI, 1.50-20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E(2), fE(2), and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR 3.14; 95% CI, 1.21-9.37), whereas E(2) and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women. Conclusions: Our findings suggest for the first time that T and possibly E(2) may be involved in the etiology of ICC. Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532-40. (C) 2011 AACR.

U2 - 10.1158/1055-9965.EPI-11-0753

DO - 10.1158/1055-9965.EPI-11-0753

M3 - Article

C2 - 21994406

VL - 20

SP - 2532

EP - 2540

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1538-7755

IS - 12

ER -