Enzymatic characterization of lipid-based drug delivery systems

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

Detaljer

Författare
  • Helena Ljusberg
  • F S Nielsen
  • M Brogard
  • Emma Troedsson
  • A Mullertz
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Livsmedelsteknik

Nyckelord

Originalspråkengelska
Sidor (från-till)328-332
TidskriftInternational Journal of Pharmaceutics
Volym298
Utgivningsnummer2
StatusPublished - 2005
PublikationskategoriForskning
Peer review utfördJa