Enzymatic synthesis of N-alkanoyl-N-methylglucamide surfactants: solvent-free production and environmental assessment

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Enzymatic synthesis of N-alkanoyl-N-methylglucamide surfactants: solvent-free production and environmental assessment. / Gaber, Yasser; Törnvall, Ulrika; Orellana Coca Åkerman, Cecilia; Amin, Magdy Ali; Hatti-Kaul, Rajni.

I: Green Chemistry, Vol. 12, Nr. 10, 2010, s. 1817-1825.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Gaber, Yasser ; Törnvall, Ulrika ; Orellana Coca Åkerman, Cecilia ; Amin, Magdy Ali ; Hatti-Kaul, Rajni. / Enzymatic synthesis of N-alkanoyl-N-methylglucamide surfactants: solvent-free production and environmental assessment. I: Green Chemistry. 2010 ; Vol. 12, Nr. 10. s. 1817-1825.

RIS

TY - JOUR

T1 - Enzymatic synthesis of N-alkanoyl-N-methylglucamide surfactants: solvent-free production and environmental assessment

AU - Gaber, Yasser

AU - Törnvall, Ulrika

AU - Orellana Coca Åkerman, Cecilia

AU - Amin, Magdy Ali

AU - Hatti-Kaul, Rajni

PY - 2010

Y1 - 2010

N2 - A biocatalysis based method for the solvent-free production of N-alkanoyl-N-methylglucamide (MEGA) surfactants was developed and used as a case study for the evaluation of different environmental assessment tools, such as the freeware package EATOS (Environmental Assessment Tool for Organic Synthesis). In order to also consider energy usage and process facilities, e. g. heating, stirring and vacuum, a complementary tool was needed; hence the EcoScale method and the use of an energy monitoring socket were also exploited. The solvent-free method followed by a simple hydrolysis step gave a final amide yield of 99% and a product essentially free of remaining substrate, N-methylglucamine (MEG). The latter is important since MEG can potentially be converted to carcinogenic nitrosamines. The absence of solvent in the reaction medium was also found to result in a significantly reduced potential environmental impact. The environmental tools used in this study were further scrutinized, and even if they represent some of the best freely available tools for evaluation of early stage process development, some points for further improvements are suggested.

AB - A biocatalysis based method for the solvent-free production of N-alkanoyl-N-methylglucamide (MEGA) surfactants was developed and used as a case study for the evaluation of different environmental assessment tools, such as the freeware package EATOS (Environmental Assessment Tool for Organic Synthesis). In order to also consider energy usage and process facilities, e. g. heating, stirring and vacuum, a complementary tool was needed; hence the EcoScale method and the use of an energy monitoring socket were also exploited. The solvent-free method followed by a simple hydrolysis step gave a final amide yield of 99% and a product essentially free of remaining substrate, N-methylglucamine (MEG). The latter is important since MEG can potentially be converted to carcinogenic nitrosamines. The absence of solvent in the reaction medium was also found to result in a significantly reduced potential environmental impact. The environmental tools used in this study were further scrutinized, and even if they represent some of the best freely available tools for evaluation of early stage process development, some points for further improvements are suggested.

U2 - 10.1039/c004548a

DO - 10.1039/c004548a

M3 - Article

VL - 12

SP - 1817

EP - 1825

JO - Green Chemistry

JF - Green Chemistry

SN - 1463-9270

IS - 10

ER -