Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmakologi och toxikologi
  • Läkemedelskemi
  • Immunologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)117-123
TidskriftTrends in Pharmacological Sciences
Volym18
Utgåva nummer4
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa