Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in eosinophils, mimicking the obese phenotype, and was restored upon eosinophil reconstitution. Ex vivo studies demonstrated that the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nitric oxide, which was restored after eosinophil reconstitution. Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed β3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-contractile function.

Detaljer

Författare
  • Sarah B. Withers
  • Ruth Forman
  • Selene Meza-Perez
  • Daniel Sorobetea
  • Kasia Sitnik
  • Thomas Hopwood
  • Catherine B. Lawrence
  • William W. Agace
  • Kathryn J. Else
  • Anthony M Heagerty
  • Marcus Svensson-Frej
  • Sheena M. Cruickshank
Enheter & grupper
Externa organisationer
  • University of Manchester
  • Technical University of Denmark
  • University of Alabama
  • Lund University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Artikelnummer44571
TidskriftScientific Reports
Volym7
StatusPublished - 2017 mar 17
PublikationskategoriForskning
Peer review utfördJa