Epigenetic alterations as biomarkers in pancreatic ductal adenocarcinoma

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood. High-throughput methods are available for miR and DNA methylation level detection. In particular, multiple promising miR level changes have been discovered. No single epigenetic biomarker that offers a sufficient specificity has been discovered yet, but patterns containing multiple independent biomarkers exist.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Gastroenterologi

Nyckelord

Originalspråkengelska
Sidor (från-till)668-673
TidskriftScandinavian Journal of Gastroenterology
Volym52
Utgivningsnummer6-7
StatusPublished - 2017 jul 3
PublikationskategoriForskning
Peer review utfördJa