Epithelial–mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.

Detaljer

Författare
  • Mohit Kumar Jolly
  • Chris Ward
  • Mathew Suji Eapen
  • Stephen Myers
  • Oskar Hallgren
  • Herbert Levine
  • Sukhwinder Singh Sohal
Enheter & grupper
Externa organisationer
  • Rice University
  • University of Newcastle upon Tyne
  • University of Tasmania
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi

Nyckelord

Originalspråkengelska
Sidor (från-till)346-358
TidskriftDevelopmental Dynamics
Volym247
Utgåva nummer3
StatusPublished - 2018 mar 1
PublikationskategoriForskning
Peer review utfördJa