Establishing outcome measures in early knee osteoarthritis

Forskningsoutput: TidskriftsbidragÖversiktsartikel


The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.


  • Carolyn A Emery
  • Jackie L Whittaker
  • Armaghan Mahmoudian
  • Ewa M Roos
  • Kim L Bennell
  • Clodagh M Toomey
  • Raylene A Reimer
  • Dylan Thompson
  • Janet L Ronsky
  • Gregor Kuntze
  • David G Lloyd
  • Thomas Andriacchi
  • Virginia B Kraus
  • Elena Losina
  • Sita Bierma-Zeinstra
  • Jos Runhaar
  • George Peat
  • Frank P Luyten
  • Lynn Snyder-Mackler
  • May Arna Risberg
  • Ali Mobasheri
  • Ali Guermazi
  • David J Hunter
  • Nigel K Arden
Enheter & grupper
Externa organisationer
  • Veterans Health Administration, Palo Alto CA
  • Keele University
  • Queen's Medical Centre, Nottingham
  • Boston University
  • Oxford Brookes University
  • University of Calgary
  • University of Alberta
  • Skåne University Hospital
  • University Hospitals Leuven
  • University of Southern Denmark
  • University of Melbourne
  • University of Bath
  • Griffith University
  • Duke University
  • Harvard University
  • Brigham and Women's Hospital, Boston
  • Erasmus University Medical Center
  • University of Delaware
  • Oslo university hospital
  • University of Sydney
  • Royal North Shore Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Ortopedi
Sidor (från-till)438-448
TidskriftNature Reviews Rheumatology
Utgåva nummer7
Tidigt onlinedatum2019 jun 14
StatusPublished - 2019
Peer review utfördJa