Estimating the distribution of the G2 phase duration from flow cytometric histograms

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Estimating the distribution of the G2 phase duration from flow cytometric histograms. / Larsson, Sara; Rydén, Tobias; Holst, Ulla; Oredsson, Stina; Johansson, Maria C.

I: Mathematical Biosciences, Vol. 211, Nr. 1, 2008, s. 1-17.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Estimating the distribution of the G2 phase duration from flow cytometric histograms

AU - Larsson, Sara

AU - Rydén, Tobias

AU - Holst, Ulla

AU - Oredsson, Stina

AU - Johansson, Maria C

PY - 2008

Y1 - 2008

N2 - A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

AB - A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

KW - Cell cycle progression

KW - Branching process

KW - G2 phase duration

KW - Flow cytometry

U2 - 10.1016/j.mbs.2007.08.009

DO - 10.1016/j.mbs.2007.08.009

M3 - Article

VL - 211

SP - 1

EP - 17

JO - Mathematical Biosciences

JF - Mathematical Biosciences

SN - 0025-5564

IS - 1

ER -