Ethanol prevents development of destructive arthritis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappa B activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness.

Detaljer

Författare
  • Ing-Marie Jonsson
  • Margareta Verdrengh
  • Mikael Brisslert
  • Sofia Lindblad
  • Maria Bokarewa
  • Ulrika Islander
  • Hans Carlsten
  • Claes Ohlsson
  • Kutty Selva Nandakumar
  • Rikard Holmdahl
  • Andrej Tarkowski
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)258-263
TidskriftProceedings of the National Academy of Sciences
Volym104
Utgivningsnummer1
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa