Etiology and pathogenesis of parkinson’s disease
Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Kapitel samlingsverk
The etiology of Parkinson’s disease (PD) is still far from fully known. In the new millennium, an increased knowledge of the genetic forms of PD has contributed to an improved understanding of underlying cellular mechanisms that are central also in sporadic PD. Although steadily improving, the challenge to fully understand the origin, function, and consequences of Lewy bodies still remains. Toxicological or viral exposure has been hypothesized to function as stressors that, together with a genetic susceptibility, precipitate the development of PD. Meanwhile the impact of these environmental factors is somewhat controversial, it is clear that old age is the single most important risk factor for PD. The improved access to molecular genetic methods has, as in many fields of medicine, reformed PD research, and this is likely where the most significant progress will be made in the near future. Due to the heterogeneous clinical features within the PD entity and the similarities to several closely related diseases, it is reasonable to take into consideration that what is today defined as PD may not be one disease, but rather several diseases with similar clinical features.
|Enheter & grupper|
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Titel på värdpublikation||Movement Disorders Curricula|
|Status||Published - 2017|
|Peer review utförd||Ja|