Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • KabiVitrum AB
  • Göteborgs universitet
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)609-14
Antal sidor6
TidskriftActa Physiologica Scandinavica
Volym126
Utgivningsnummer4
StatusPublished - 1986 apr
PublikationskategoriForskning
Peer review utfördJa