Excitatory amino acid receptors and ischemic brain damage in the rat

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The excitatory amino acid glutamate has been suggested to be an important mediator of the selective CA1 hippocampal damage which follows transient cerebral ischemia. In order to evaluate the possible involvement of altered glutamate receptor regulation in the expression of the delayed neuronal necrosis following ischemia, we have determined the density of glutamate receptor subtypes in the rat hippocampus following transient ischemia. We report a transient reversible decrease in [3H]AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding sites (presumably representing quisqualate receptors) followed by a long term loss of binding at 2 days postischemia which precedes neuronal loss. In contrast, no change was noted in the N-methyl-d-aspartate or kainic acid binding sites over this time period.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Lund University
  • University of California, Irvine
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)119-124
Antal sidor6
TidskriftNeuroscience Letters
Volym73
Utgåva nummer2
StatusPublished - 1987 jan 14
PublikationskategoriForskning
Peer review utfördJa