Excitatory amino acids and cerebrovascular tone

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Levels of excitatory amino acids in the brain extracellular fluid compartment rise during pathological conditions in the brain such as ischaemia, anoxia and epilepsy. One such amino acid, glutamate, is present in sensory nerve fibres innervating, for example, cerebral vessels. Enhanced levels of circulating glutamate and aspartate are found in migraine sufferers. The present study examined whether excitatory amino acids, in concentrations found in the brain extracellular fluid compartment during pathological conditions, exert a direct effect on cerebrovascular tone. As tested in flow-regulating pial arteries from rat, cat and man, no such constrictive or dilatory effect was obtained.


Enheter & grupper
Externa organisationer
  • Lund University
Sidor (från-till)483-485
Antal sidor3
TidskriftActa Physiologica Scandinavica
Utgåva nummer3
StatusPublished - 1989 jan 1
Peer review utfördJa