Experimental results from a preclinical X-ray phase-contrast CT scanner

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating alignment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quantitatively accurate Hounsfield units in attenuation and phase. Moreover, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applications (in the long-term future).

Detaljer

Författare
  • Arne Tapfer
  • Martin Bech
  • Astrid Velroyen
  • Jan Meiser
  • Juergen Mohr
  • Marco Walter
  • Joachim Schulz
  • Bart Pauwels
  • Peter Bruyndonckx
  • Xuan Liu
  • Alexander Sasov
  • Franz Pfeiffer
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Radiologi och bildbehandling

Nyckelord

Originalspråkengelska
Sidor (från-till)15691-15696
TidskriftProceedings of the National Academy of Sciences
Volym109
Utgivningsnummer39
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa