Exploring the multifaceted nature of the common lymphoid progenitor compartment.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Linköping University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Utvecklingsbiologi
  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)121-126
TidskriftCurrent Opinion in Immunology
Volym39
StatusPublished - 2016
PublikationskategoriForskning
Peer review utfördJa