Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The expression of mRNA coding for brain-derived neurotrophic factor (BDNF) and for its functional receptor, the full-length tyrosine kinase receptor trkB (trkB mRNA), was examined in early postnatal and adult rat retina by in situ hybridization using digoxygenin and radioactively-labeled oligonucleotide probes. BDNF and trkB mRNAs are expressed in the ganglion cell layer at postnatal-days (PN) 1, 4, 7, 14, 60, in proximal neuroblastic layer (PN 1, 4, 7), and proximal inner nuclear layer (PN 14, 60). Subpopulations of developing and mature retinal cells are thus capable of synthesizing BDNF.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)96-9
TidskriftNeuroscience Letters
Volym183
Utgåva nummer1-2
StatusPublished - 1995 jan 2
PublikationskategoriForskning
Peer review utfördJa