Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)288-296
TidskriftCardiovascular Research
Volym101
Utgåva nummer2
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa

Nedladdningar

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Relaterad forskningsoutput

Bhattachariya, A., 2014, Vascular Physiology, Lund University. 89 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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