F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

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We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.


  • Karen Juul Mylam
  • Lale Kostakoglu
  • Martin Hutchings
  • Morton Coleman
  • Dominick Lamonica
  • Myron S. Czuczman
  • Louis F. Diehl
  • Anne L. Nielsen
  • Paw Jensen
  • Annika Loft
  • Helle W. Hendel
  • Victor Iyer
  • Sirpa Leppa
  • Sirkku Jyrkkio
  • Harald Holte
  • Dorte Gillstrom
  • Per B. Hansen
  • Marko Seppanen
  • Karin Hjorthaug
  • Peter de Nully Brown
  • Lars M. Pedersen
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi


Sidor (från-till)2005-2012
TidskriftLeukemia & Lymphoma
StatusPublished - 2015
Peer review utfördJa