Familial breast and ovarian cancer: a Swedish population-based register study

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Familial breast and ovarian cancer : a Swedish population-based register study. / Anderson, H; Bladström, A; Olsson, Håkan; Möller, Torgil.

I: American Journal of Epidemiology, Vol. 152, Nr. 12, 15.12.2000, s. 1154-63.

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Anderson, H, Bladström, A, Olsson, H & Möller, T 2000, 'Familial breast and ovarian cancer: a Swedish population-based register study', American Journal of Epidemiology, vol. 152, nr. 12, s. 1154-63.

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Anderson, H ; Bladström, A ; Olsson, Håkan ; Möller, Torgil. / Familial breast and ovarian cancer : a Swedish population-based register study. I: American Journal of Epidemiology. 2000 ; Vol. 152, Nr. 12. s. 1154-63.

RIS

TY - JOUR

T1 - Familial breast and ovarian cancer

T2 - American journal of hygiene

AU - Anderson, H

AU - Bladström, A

AU - Olsson, Håkan

AU - Möller, Torgil

PY - 2000/12/15

Y1 - 2000/12/15

N2 - A cohort of offspring of mothers with breast or ovarian cancer diagnosed in 1958-1993 was established using Swedish population-based registers. The children (n = 158,041) were born between 1941 and 1993, and their cancer incidence was followed between 1961 and 1993. A total of 3,257 tumors in 3,102 children were found. Observed numbers of cases were compared with expected numbers based on national calendar year-, age-, and sex-specific incidences. For daughters of women with breast cancer, the standardized morbidity ratios for being diagnosed with breast cancer and ovarian cancer before age 50 years were 1.99 (95% confidence interval (CI): 1.86, 2.14) and 1.28 (95% CI: 1.05, 1.54), respectively. The corresponding figures for daughters of women with ovarian cancer were 1.79 (95% CI: 1.55, 2.07) and 2.38 (95% CI: 1.77, 3.12). The risks were raised if the mother's cancer was diagnosed at a young age, the mother had multiple breast/ovarian diagnoses, or there was a sister with breast/ovarian cancer. Among all offspring, increased risks were found for thyroid cancer, testicular cancer, and malignant melanoma, while lung cancer risk was decreased if the mother had had breast cancer. The authors developed a variance estimator for the standardized morbidity ratio to cope with overdispersion due to dependency within families.

AB - A cohort of offspring of mothers with breast or ovarian cancer diagnosed in 1958-1993 was established using Swedish population-based registers. The children (n = 158,041) were born between 1941 and 1993, and their cancer incidence was followed between 1961 and 1993. A total of 3,257 tumors in 3,102 children were found. Observed numbers of cases were compared with expected numbers based on national calendar year-, age-, and sex-specific incidences. For daughters of women with breast cancer, the standardized morbidity ratios for being diagnosed with breast cancer and ovarian cancer before age 50 years were 1.99 (95% confidence interval (CI): 1.86, 2.14) and 1.28 (95% CI: 1.05, 1.54), respectively. The corresponding figures for daughters of women with ovarian cancer were 1.79 (95% CI: 1.55, 2.07) and 2.38 (95% CI: 1.77, 3.12). The risks were raised if the mother's cancer was diagnosed at a young age, the mother had multiple breast/ovarian diagnoses, or there was a sister with breast/ovarian cancer. Among all offspring, increased risks were found for thyroid cancer, testicular cancer, and malignant melanoma, while lung cancer risk was decreased if the mother had had breast cancer. The authors developed a variance estimator for the standardized morbidity ratio to cope with overdispersion due to dependency within families.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Breast Neoplasms

KW - Confidence Intervals

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Incidence

KW - Middle Aged

KW - Ovarian Neoplasms

KW - Population Surveillance

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Survival Rate

KW - Sweden

M3 - Article

VL - 152

SP - 1154

EP - 1163

JO - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 12

ER -