Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants

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Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants. / Kharazmi, Elham; da Silva Filho, Miguel I.; Pukkala, Eero; Sundquist, Kristina; Thomsen, Hauke; Hemminki, Kari.

I: British Journal of Haematology, Vol. 159, Nr. 5, 2012, s. 585-588.

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T1 - Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants

AU - Kharazmi, Elham

AU - da Silva Filho, Miguel I.

AU - Pukkala, Eero

AU - Sundquist, Kristina

AU - Thomsen, Hauke

AU - Hemminki, Kari

PY - 2012

Y1 - 2012

N2 - Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3.2 (95% confidence interval 1.55.9) and 162.6 (70.2320.4), respectively. The present data constitute the first demonstration of familial risk for singleton siblings; the high risk for twins is believed to result from shared prenatal blood circulation. The data suggest that currently unidentified genetic loci underlie these observed familial effects.

AB - Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3.2 (95% confidence interval 1.55.9) and 162.6 (70.2320.4), respectively. The present data constitute the first demonstration of familial risk for singleton siblings; the high risk for twins is believed to result from shared prenatal blood circulation. The data suggest that currently unidentified genetic loci underlie these observed familial effects.

KW - familial cancer

KW - standardized incidence ratio

KW - childhood acute

KW - lymphocytic leukaemia

KW - susceptibility genes

U2 - 10.1111/bjh.12069

DO - 10.1111/bjh.12069

M3 - Article

VL - 159

SP - 585

EP - 588

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 5

ER -