Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{da8876e3f7d04bc6a796c96895beadf9,
title = "Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment",
abstract = "Background: Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin affects the fasting level of GH. Methods: We examined the association between GH and IMT in 4425 individuals (aged 46-68 years) included in the baseline examination (1991-1994) of the Malm{\"o} Diet and Cancer cardiovascular cohort (MDC-CC). From that cohort we then studied 472 individuals (aged 50-70 years) who also participated (1994-1999) in the β-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS), a randomized, double blind, placebo-controlled, single-center clinical trial. Using multivariate linear regression models we related the change in GH-levels at 12 months compared with baseline to treatment with 40 mg fluvastatin once daily. Results: In MDC-CC fasting values of GH exhibited a positive cross-sectional relation to the IMT at the carotid bulb independent of traditional cardiovascular risk factors (p = 0.002). In a gender-stratified analysis the correlation were significant for males (p = 0.005), but not for females (p = 0.09). Treatment with fluvastatin was associated with a minor reduction in the fasting levels of hs-GH in males (p = 0.05) and a minor rise in the same levels among females (p = 0.05). Conclusions: We here demonstrate that higher fasting levels of GH are associated with thicker IMT in the carotid bulb in males. Treatment with fluvastatin for 12 months only had a minor, and probably not clinically relevant, effect on the fasting levels of hs-GH.",
keywords = "Cardiovascular disease, Growth hormone, Imt, Lipids, Statins",
author = "Erik Hallengren and Peter Almgren and Maria Rosvall and Gerd {\"O}stling and Margaretha Persson and Andreas Bergmann and Joachim Struck and Gunnar Engstr{\"o}m and Bo Hedblad and Olle Melander",
year = "2017",
month = "5",
day = "16",
doi = "10.1186/s12872-017-0563-9",
language = "English",
volume = "17",
journal = "BMC Cardiovascular Disorders",
issn = "1471-2261",
publisher = "BioMed Central",
number = "1",

}