Fecal-Derived Phenol Induces Egg-Laying Aversion in Drosophila

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Feces is an abundant, rich source of energy, utilized by a myriad of organisms, not least by members of the order Diptera, i.e., flies. How Drosophila melanogaster reacts to fecal matter remains unclear. Here, we examined oviposition behavior toward a range of fecal samples from mammals native to the putative Southeast African homeland of the fly. We show that D. melanogaster display a strong oviposition aversion toward feces from carnivorous mammals but indifference or even attraction toward herbivore dung. We identify a set of four predictor volatiles, which can be used to differentiate fecal from non-fecal matter, as well as separate carnivore from herbivore feces. Of these volatiles, phenol—indicative of carnivore feces—confers egg-laying aversion and is detected by a single class of sensory neurons expressing Or46a. The Or46a-expressing neurons are necessary and sufficient for oviposition site aversion. We further demonstrate that carnivore feces—unlike herbivore dung—contain a high rate of pathogenic bacteria taxa. These harmful bacteria produce phenol from L-tyrosine, an amino acid specifically enriched in high protein diets, such as consumed by carnivores. Finally, we demonstrate that carnivore feces, as well as phenol, is also avoided by a ball-rolling species of dung beetle, suggesting that phenol is a widespread avoidance signal because of its association with pathogenic bacteria.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Zoologi
  • Biokemi och molekylärbiologi
Originalspråkengelska
Sidor (från-till)2762-2769
Antal sidor8
TidskriftCurrent Biology
Volym26
Utgåva nummer20
StatusPublished - 2016 okt 24
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Suzan Mansourian, 2018 maj, Lund: Lund University, Faculty of Science, Department of Biology. 122 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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