First comprehensive tool for screening pain in Parkinson's disease: the King's Parkinson's Disease Pain Questionnaire

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background and purpose: Pain is highly prevalent in Parkinson's disease (PD), impacting patients’ ability, mood and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multicentre study was aimed at testing the validity of this screening tool. Methods: First, a comparison between the KPPQ scores of patients and matched controls was performed. Next, convergent validity, reproducibility (test–retest) and diagnostic performance of the questionnaire were analysed. Results: Data from 300 patients and 150 controls are reported. PD patients declared significantly more pain symptoms than controls (3.96 ± 2.56 vs. 2.17 ± 1.39; P < 0.0001). The KPPQ convergent validity was high with KPPS total score (rS = 0.80) but weak or moderate with other pain assessments. Test–retest reliability was satisfactory with kappa values ≥0.65 except for item 5, Dyskinetic pains (κ = 0.44), and the intraclass correlation coefficient (ICC) for the KPPQ total score was 0.98. After the scores of the KPPS were adapted for screening (0, no symptom; ≥1, symptom present), a good agreement was found between the KPPQ and the KPPS (ICC = 0.88). A strong correlation (rS = 0.80) between the two instruments was found. The diagnostic parameters of the KPPQ were very satisfactory as a whole, with a global accuracy of 78.3%–98.3%. Conclusions: These results suggest that the KPPQ is a useful, reliable and valid screening instrument for pain in PD to advance patient-related outcomes.


  • P. Martinez-Martin
  • A. M. Rizos
  • J. Wetmore
  • A. Antonini
  • P. Odin
  • S. Pal
  • R. Sophia
  • C. Carroll
  • D. Martino
  • C. Falup-Pecurariu
  • B. Kessel
  • T. Andrews
  • D. Paviour
  • C. Trenkwalder
  • K. R. Chaudhuri
  • MDS Non-motor PD Study Group
Enheter & grupper
Externa organisationer
  • CIBER Enfermedades Neurodegenerativas (CIBERNED)
  • King's College Hospital
  • University of Padova
  • Derriford Hospital
  • University of Calgary
  • Transylvania University Brasov
  • Guy's and St Thomas' NHS Foundation Trust
  • St George's Hospital, London
  • University Medical Center Göttingen
  • Carlos III Health Institute
  • King's College London
  • Forth Valley Royal Hospital
  • Yeovil District Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi


Sidor (från-till)1255-1261
Antal sidor7
TidskriftEuropean Journal of Neurology
Utgåva nummer10
StatusPublished - 2018
Peer review utfördJa