Flow-through picoliter dispenser: A new approach for solvent elimination in FT-IR spectroscopy

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title = "Flow-through picoliter dispenser: A new approach for solvent elimination in FT-IR spectroscopy",
abstract = "A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-through microdispenser as a possible interface for flow system-FT-IR analysis has the capability of meeting the demands of hyphenated miniaturized liquid handling systems (e.g., mu-HPLC, microhigh performance liquid chromatography), as it successfully provides highly stable, reliable and reproducible operating conditions for liquid handling in the picoliter range. Moreover, an increase in sensitivity for FT-IR measurements could be achieved, lowering the mass detection limit of sugars (such as the investigated sucrose) to 53 picograms. As is demonstrated on the example of an HPLC separation of a mixture of glucose and fructose, interfacing LC systems to FT-IR using a piezoactuated flow-through microdispenser is a feasible and promising approach.",
keywords = "micro-liquid handling, FT-IR, infrared spectroscopy, Fourier transform, flow-through microdispenser, solvent elimination",
author = "M Haberkorn and J Frank and M Harasek and Johan Nilsson and Thomas Laurell and B Lendl",
year = "2002",
doi = "10.1366/000370202760171581",
language = "English",
volume = "56",
pages = "902--908",
journal = "Applied Spectroscopy",
issn = "1943-3530",
publisher = "Society for Applied Spectroscopy",
number = "7",