Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Abstract

Fluid biomarkers, including cerebrospinal fluid (CSF) biomarkers and blood-based biomarkers, may reflect different pathological processes in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The most used biomarkers are CSF β-amyloid42, total tau, phosphorylated tau, and neurofilament light, which have been studied for diagnosis, prognosis, and treatment follow-up and in relation to genetics and neuroimaging. These biomarkers are now increasingly used in research, drug development, and clinical settings to increase our understanding of AD and FTD and to improve patient management. Recent progress in stable, automated assays for CSF biomarkers and ultrasensitive assays for blood-based biomarkers and the incorporation of fluid biomarkers in clinical practice and in clinical trials have accelerated the field. Key issues for further research include more extensive studies of the earliest stages of neurodegenerative diseases, better biomarkers for distinct proteinopathies, and the creation of universally accepted guidelines specifying the role of fluid biomarkers in relation to clinical measures and neuroimaging findings.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Sahlgrenska Academy
  • Sahlgrenska University Hospital
  • University College London
  • UK Dementia Research Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Titel på värdpublikationNeurodegeneratIve Diseases
Undertitel på gästpublikationClinical Aspects, Molecular Genetics and Biomarkers
FörlagSpringer International Publishing AG
Sidor221-252
Antal sidor32
ISBN (elektroniskt)9783319729381
ISBN (tryckt)9783319729374
StatusPublished - 2018 jan 1
PublikationskategoriForskning
Peer review utfördJa