Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.


  • Martine M. Ros
  • H. B. Bas Bueno-de-Mesquita
  • Frederike L. Buchner
  • Katja K. H. Aben
  • Ellen Kampman
  • Lars Egevad
  • Kim Overvad
  • Anne Tjonneland
  • Nina Roswall
  • Francoise Clavel-Chapelon
  • Rudolf Kaaks
  • Jenny Chang-Claude
  • Heiner Boeing
  • Steffen Weikert
  • Antonia Trichopoulou
  • Philippos Orfanos
  • Georgia Stasinopulou
  • Calogero Saieva
  • Vittorio Krogh
  • Paolo Vineis
  • Rosario Tumino
  • Amalia Mattiello
  • Petra H. M. Peeters
  • Franzel J. B. van Duijnhoven
  • Eiliv Lund
  • Inger T. Gram
  • Maria D. Chirlaque
  • Aurelio Barricarte
  • Laudina Rodriguez
  • Esther Molina
  • Carlos Gonzalez
  • Miren Dorronsoro
  • Roy Ehrnström
  • Borje Ljungberg
  • Naomi E. Allen
  • Andrew W. Roddam
  • Kay-Tee Khaw
  • Nick Wareham
  • Paolo Boffetta
  • Nadia Slimani
  • Dominique S. Michaud
  • Lambertus A. L. M. Kiemeney
  • Elio Riboli
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi


Sidor (från-till)2695-2708
TidskriftInternational Journal of Cancer
Utgåva nummer11
StatusPublished - 2011
Peer review utfördJa