Fluorescence diffuse optical tomography using upconverting nanoparticles

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.

Detaljer

Författare
  • Can Xu
  • Johan Axelsson
  • Stefan Andersson-Engels
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Atom- och molekylfysik och optik

Nyckelord

Originalspråkengelska
TidskriftApplied Physics Letters
Volym94
Utgåva nummer25
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa

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