FragMAX: the fragment-screening platform at the MAX IV Laboratory

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Advances in synchrotron storage rings and beamline automation have pushed data-collection rates to thousands of data sets per week. With this increase in throughput, massive projects such as in-crystal fragment screening have become accessible to a larger number of research groups. The quality of support offered at large-scale facilities allows medicinal chemistry-focused or biochemistry-focused groups to supplement their research with structural biology. Preparing the experiment, analysing multiple data sets and prospecting for interesting complexes of protein and fragments require, for both newcomers and experienced users, efficient management of the project and extensive computational power for data processing and structure refinement. Here, FragMAX, a new complete platform for fragment screening at the BioMAX beamline of the MAX IV Laboratory, is described. The ways in which users are assisted in X-ray-based fragment screenings and in which the fourth-generation storage ring available at the facility is best exploited are also described.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • AstraZeneca
  • Lund University
  • SARomics Biostructures AB
  • Helmholtz-Zentrum Berlin (HZB)
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Strukturbiologi
Originalspråkengelska
Sidor (från-till)771-777
Antal sidor7
TidskriftActa Crystallographica Section D: Structural Biology
Volym76
Utgåva nummerPt 8
StatusPublished - 2020 aug 1
PublikationskategoriForskning
Peer review utfördJa