Frequency and patterns of reassortment in natural influenza A virus infection in a reservoir host

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Abstract

Influenza A viruses (IAV) can dramatically alter both genotype and phenotype at a rapid rate as a product of co-infection and reassortment. Avian IAV exhibit high levels of phylogenetic incongruence, suggesting high levels of reassortment in the virus reservoir. Using a natural-experimental system, we reconstructed relationships amongst 92 viruses across 15 subtypes from 10 Mallards in an autumn season. Phylogenetic analyses estimated that 56% of the isolated viruses were reassorted. Network analysis demonstrated different patterns of reassortment and limited exchange of segments between primary and secondary infections. No clear patterns of linkage between segments were found, and patterns within a season were likely the consequence of continued introduction of new constellations, high viral load and diversity in the wild bird reservoir, and co-infections. This is the first IAV study to implement multiple tools available for elucidating factors governing reassortment patterns in naturally infected Mallards.

Detaljer

Författare
  • Michelle Wille
  • Conny Tolf
  • Alexis Avril
  • Neus Latorre-Margalef
  • Sofie Wallerström
  • Björn Olsen
  • Jonas Waldenström
Externa organisationer
  • Linnaeus University
  • Agricultural research for develompent (CIRAD) Centre de Recherche de Montpellier
  • Uppsala universitet
  • Karolinska Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Zoologi
  • Evolutionsbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)150-160
Antal sidor11
TidskriftVirology
Volym443
Utgåva nummer1
StatusPublished - 2013 aug 15
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa