From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

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From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. / Hattangadi, Shilpa M.; Wong, Piu; Zhang, Lingbo; Flygare, Johan; Lodish, Harvey F.

I: Blood, Vol. 118, Nr. 24, 2011, s. 6258-6268.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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Hattangadi, Shilpa M. ; Wong, Piu ; Zhang, Lingbo ; Flygare, Johan ; Lodish, Harvey F. / From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. I: Blood. 2011 ; Vol. 118, Nr. 24. s. 6258-6268.

RIS

TY - JOUR

T1 - From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

AU - Hattangadi, Shilpa M.

AU - Wong, Piu

AU - Zhang, Lingbo

AU - Flygare, Johan

AU - Lodish, Harvey F.

PY - 2011

Y1 - 2011

N2 - This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)

AB - This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)

U2 - 10.1182/blood-2011-07-356006

DO - 10.1182/blood-2011-07-356006

M3 - Review article

C2 - 21998215

VL - 118

SP - 6258

EP - 6268

JO - Blood

JF - Blood

SN - 1528-0020

IS - 24

ER -