Further important sensitizers in patients sensitive to fragrances - I. Reactivity to 14 frequently used chemicals

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The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and I of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series 1 (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral(R) is the most important single chemical.


  • PJ Frosch
  • JD Johansen
  • T Menne
  • C Pirker
  • SC Rastogi
  • KE Andersen
  • Magnus Bruze
  • A Goossens
  • JP Lepoittevin
  • IR White
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi


Sidor (från-till)78-85
TidskriftContact Dermatitis
Utgåva nummer2
StatusPublished - 2002
Peer review utfördJa