Further important sensitizers in patients sensitive to fragrances - II. Reactivity to essential oils

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title = "Further important sensitizers in patients sensitive to fragrances - II. Reactivity to essential oils",
abstract = "In order to find sensitizers additional to the current fragrance mix (FM) a series of fragrance materials (series II) was evaluated in 6 dermatological centres in Europe. 11 of the test materials were essential oils, the remaining 7 being either mixtures of isomers or simple chemicals of frequent usage in the perfume industry. 1606 patients were consecutively tested with series II and 8{\%} FM. Each patient was classified regarding a history of adverse reactions to scented products: certain, probable, questionable, none. Reactions to FM occurred most frequently in 11.4{\%} of the subjects. The 6 materials with the highest reactivity after the FM were ylang-ylang oil (YY) I (2.6{\%}), YY II (2.5{\%}), lemongrass oil (1.6{\%}), narcissus absolute (1.3{\%}), jasmine absolute (1.2{\%}) and sandalwood oil (0.9{\%}). 48 (3.0{\%}) of the patients reacted only to materials of series II and not to FM. 6.0{\%} of 1606 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 22.9{\%}, to series II and FM in 15.6{\%} and to series II only in 5.2{\%}. 63.5{\%} of the patients reacting to both FM and 1 of the materials of series II had some type of positive fragrance history, which was higher in comparison to those with isolated reactions to FM (46.2{\%} of 121) or to series II, respectively, (45.8{\%} of 48). However, this difference was not statistically significant. In conclusion, the materials of series II identified a further subset of patients with a fragrance problem, which would have been missed by the current FM as the single screening tool for patch testing.",
keywords = "contact allergy, essential oils, fragrance mix, fragrances, history of, patch testing, fragrance sensitivity",
author = "PJ Frosch and JD Johansen and T Menne and C Pirker and SC Rastogi and KE Andersen and Magnus Bruze and A Goossens and JP Lepoittevin and IR White",
year = "2002",
doi = "10.1034/j.1600-0536.2002.470204.x",
language = "English",
volume = "47",
pages = "279--287",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "5",