Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair: a systematic review and meta-analysis

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Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair : a systematic review and meta-analysis. / Teimourian, Anahid; Donoso, Felipe; Stenström, Pernilla; Arnadottir, Helena; Arnbjörnsson, Einar; Lilja, Helene; Salö, Martin.

I: BMC Pediatrics, Vol. 20, 400, 24.08.2020.

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TY - JOUR

T1 - Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair

T2 - a systematic review and meta-analysis

AU - Teimourian, Anahid

AU - Donoso, Felipe

AU - Stenström, Pernilla

AU - Arnadottir, Helena

AU - Arnbjörnsson, Einar

AU - Lilja, Helene

AU - Salö, Martin

PY - 2020/8/24

Y1 - 2020/8/24

N2 - BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.METHODS: The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.RESULTS: Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed < 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight < 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate.CONCLUSION: Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.

AB - BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.METHODS: The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.RESULTS: Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed < 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight < 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate.CONCLUSION: Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.

U2 - 10.1186/s12887-020-02295-3

DO - 10.1186/s12887-020-02295-3

M3 - Article

C2 - 32831054

VL - 20

JO - BMC Pediatrics

JF - BMC Pediatrics

SN - 1471-2431

M1 - 400

ER -